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KMID : 0370219850290010039
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Yakhak Hoeji
1985 Volume.29 No. 1 p.39 ~ p.42
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Synthesis and Reactivity of Zwitterionic Bicyclic Imidazo-thiazole Derivatives
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박상우/Park SW
김동찬/Kim DC
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Abstract
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Betaines of bicyclic imidazo-thiazoles were synthesized by the reaction of electrophiles such as methyl isocyanate, methyl isothiocyanate, allyl isothiocyanate and ketene with 3-methyl and 3-phenyl-5,6-dihydroimidazo[2,1-b]thiazole. In this reaction, the methyl group which was substituted at 3-position increased the yields of the products in comparison with those from phenyl group substituted substrates. Also, the betaines reacted with methyl iodide to give imidazo-thiazolium salts which were unstable at high temperature and converted the quaternary ammonium salts of original biheterocycles.
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